Biodegradable potato starch-tara gum (PS-TG) based films were produced by the casting method using a film-forming solution in a 100:0, 95:5 and 90:10 ratio (4 g biopolymers/100 g FFS) and glycerol as a plasticizer, and then were characterized based on their physical, mechanical, and structural properties, measured using classical methods. Andean native potato starch Ocucuri negra variety, was used to prepare the blends. Results showed that control film (PS-TG100:0) presented the highest (p<0.05) moisture content, water vapor permeability (WVP) (1.03  0,04*10-10 g. m-1 s-1 Pa-1), luminosity and a*, as well as the best barrier to radiation in the UV and visible wavelength region, but also showed the lowest solubility in water and degree of swelling. Films showed a significant reduction (p<0.05) in WVP and opacity (PS-TG95:5), and a great increase (p<0.05) in b*, and tensile strength (from 1.2 to 3.6 MPa) and elongation at break (from 8.4 to 47.8%) as a function of the higher gum concentration (PS-TG90:10). Hence, the tara gum had an impact on the vapor barrier and firmness of the films. FTIR spectra showed in each film a characteristic broad band of polymeric O-H group at 3000-3500 cm1 and other bands ascribed to stretch vibration of –C–O of –CH–O–bonds and –C–O–C group. The SEM micrographs of surface and cross-section morphology showed a slight rough surface without any crack or pores for control film, whereas PS-TG based films exhibited a homogeneous and continuous phase suggesting good compatibility and film forming ability among those biopolymers. Developed PS-TG films presented suitable physical along with strong mechanical and vapor barrier properties, indicating their potential use as biodegradable packaging material for food preservation.