Jaboticaba peel is a great source of phytochemicals, as anthocyanins, ellagic acid and tannins. Several health benefits have been attributed to these bioactive compounds, such as antioxidant and antiobesogenic effects. We evaluated the antiobesogenic effect of freeze-dried jaboticaba peel supplementation (FJP) in induced obese rats. Therefore, 24 Wistar rats were divided in four groups: AIN-93M normal control diet; HFF (obese control) feed with high-fat and fructose diet; Prevention FJP (P.FJP) and Treatment FJP (T.FJP) feed with HFF diet supplemented with 2% of FJP for 12 and 6 weeks, respectively. The weight gain and diet intake were monitored. After 12 experimental weeks, the animals were euthanized, blood was collected and liver and adipose tissues were weighed. The serum leptin, total cholesterol and HDL cholesterol were measured. The liver were freeze-dried and analyzed by Bligh & Dyer. We done T test among AIN-93M and HFF groups and ANOVA followed Tukey’s test among HFF and supplemented groups. The energy intake was not different between the groups. Weight gain, epididymal adipose tissue, mesenteric adipose tissue and the retroperitoneal adipose tissue weight, as well as the fat percentage in the liver were higher in the HFF group compared to AIN-93M group. The FJP supplementation for 6 or 12 weeks reversed the weight gain and fat accumulation in the adipose tissues and liver. The total cholesterol was not different between groups, but HDL cholesterol was lower in HFF group compared to AIN-93M group. P.FJP group shows increase in HDL cholesterol level, but the T.FJP group was not different from HFF group. Serum leptin was not different between HFF and supplemented groups. The FJP shows a potent antiobesogenic effect and ameliorates the lipid profile in the animals of prevention group can be used as an ally in the prevention and treatment of obesity.