Mangaba agroindustrial residue is a source to obtain bioactive compounds. The extraction represents an important step in obtaining these compounds from residues, its efficiency depends on several factors such as the type of method, time, solvent polarity, solvent:residue ratio and temperature. There are several extraction techniques, among them, the use of ultrasound has promoted greater extraction yield due to the cavitation effect that favors mass transfer between solvent and sample. Thus, the aim of this study was the optimization of the extraction of bioactive compounds from mangaba residue by ultrasound assisted and maceration techniques. The mangaba seeds were dried, triturated, sieved and sterilized. In both extraction methods, a central composite rotational design was employed and ethanol concentration (0 to 80%), solvent-residue ratio (10 to 50 mL/g) and extraction time (10 to 90 min) were varied. The extracts were analyzed for total phenolic (TPC) and total flavonoids (TF) compounds and antioxidant activity (AA) by the FRAP, DPPH and ABTS methods. The maximum TPC and TF contents were of 502.18 and 757.90 mg gallic acid equivalent/100g; 34.15 and 51.75 mg quercetin/100g, respectively obtained by ultrasound and maceration, respectively. The extracts obtained by ultrasound also showed higher AA (ABTS=26.92 µmol of TROLOX/g, FRAP=30.10 µmol of TROLOX/g and DPPH= 10.95 µmol of TROLOX/g). Ethanol concentration and solvent-residue ratio were the most significant parameters to extraction of antioxidant polyphenolic compounds by both techniques. The extraction conditions of bioactive compounds from mangaba seeds flour was optimized using maceration and ultrasound methods, being this last the most efficient to this purpose.