Nowadays, there is a worldwide demand in the production of innovative packaging that release active compounds to increase the shelf life of perishable food products. Therefore, this study produced methylcellulose films functionalized with poly-ε-caprolactone nanocapsules entrapped β-carotene. The nanoparticles were produced by the nanoprecipitation method, and 10, 30, and 50% of nanoparticles colloidal solution was added in the filmogenic solution of methylcellulose. The films were characterized by the mechanical, physicochemical properties, antioxidant activity, and release of β-carotene from the polymeric matrix to a food simulant. The results demonstrate satisfactory mechanical properties, however, the addition of nanoparticles in the filmogenic solution decreased the Young's Modulus and increasing the elongation at break. Regarding light transmission, the incorporation of β-carotene nanoparticles promoted a decrease in the percentage of ultraviolet ray’s transmittance through the film matrix, as well as visible light. The incorporation of poly-ε-caprolactone nanoparticles improved the antioxidant activity of the films, which was proportional to the concentration of nanoparticles used in the filmogenic solution. The release of β-carotene reached a maximum value of 10.93 µg/g film containing 70% nanoparticles, which was a desired profile for food application. Finally, the methylcellulose films functionalized with poly-ε-caprolactone nanocapsules can release β-carotene, and therefore, can be considered as a new alternative material for food conservation, with a potential to increase the shelf life of perishable food products.