ANTIOXIDANT AND CYTOTOXIC EFFECTS OF HYBRID VITIS VINIFERA L. VARIETIE SWEET JUBILEE ON PROSTATE CANCER CELL LINES
Details
- Presentation type: Pôster
- Track: Food and health (AS)
- Keywords: Câncer; fruits; Antioxidant;
- 1 Universidade Federal do Estado do Rio de Janeiro
- 2 Universidade Federal do Estado do Rio de Janeiro / Universidade Federal do Estado do Rio de Janeiro
- 3 INCA
- 4 UNIRIO - Programa de Pos Graduação em Alimentos e Nutrição
- 5 Food and Laboratory of Functional Foods, Federal University of Rio de Janeiro State - UNIRIO, Pasteur Av. 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
ANTIOXIDANT AND CYTOTOXIC EFFECTS OF HYBRID VITIS VINIFERA L. VARIETIE SWEET JUBILEE ON PROSTATE CANCER CELL LINES
Anderson Junger Teodoro
Food and Laboratory of Functional Foods, Federal University of Rio de Janeiro State - UNIRIO, Pasteur Av. 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
Abstract
The benefits of grape consumption are widely recognized and mostly due to phenolic compounds. These beneficial effects will depend on the antioxidant activity of these compounds on grape and its form of cultivation and production. The aim of this study was to evaluate the antioxidant activity and cytotoxic effects of hybrid Vitis vinifera L. varieties Sweet Jubillee extracts (SJE) on human prostate cancer cell lines. Our results showed that SJE present high content of phenolic compounds ( 1047.21 ± 63.30 mg AGE/g) and strong antioxidant activity by DPPH reduction (90.42%), FRAP (129.69 mmol ferrous sulphate/g) and ORAC (131.61µmol TE/g) assays. A reduction in cell viability was identified in DU-145 (46.66%) and PC-3 (48.79%) cells after 48h treatment with SJE by MTT assay. Flow cytometry showed that the treatment with the SJE promote an inhibitory impact on cell development due to G0/ G1 arrest and high rate of early and late apoptotic cells compared to control group. The findings suggested that extract of Sweet Jubillee has its own potential as cancer chemotherapeutic agent against prostate cancer cell.
Streamline your Scholarly Event
With nearly 200,000 papers published, Galoá empowers scholars to share and discover cutting-edge research through our streamlined and accessible academic publishing platform.
Learn more about our products:
