HYPOGLYCEMIC EFFECT OF EXTRACT FROM Eugenia involucrata FRUITS IN TYPE 2 DIABETES MELLITUS MODEL IN RATS: A PRELIMINARY STUDY

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Detalhes
  • Tipo de apresentação: Pôster
  • Eixo temático: Alimentação e saúde (AS)
  • Palavras chaves: cherry of the rio grande; DM2; antihyperglycemic effect;
  • 1 Universidade Federal de Santa Maria
  • 2 Universidade Federal de Santa Catarina

HYPOGLYCEMIC EFFECT OF EXTRACT FROM Eugenia involucrata FRUITS IN TYPE 2 DIABETES MELLITUS MODEL IN RATS: A PRELIMINARY STUDY

Franciele Aline Smaniotto

Universidade Federal de Santa Maria

Resumo

Eugenia involucrata DC., known as Cherry of the Rio Grande is a native plant from Brazil and it is considered an important source of bioactive compounds still little invetigated. We evaluated the effect of the ethanolic extract from E. involucrata fruits on biochemical parameters in type 2 diabetes (DM2) model in adult male Wistar rats (CEUA/UFSM n. 2954100818). Animals were initially divided into two groups: control group (normal diet) and diabetic group (hypercaloric diet). On the 13th day after starting the hypercaloric diet (84.3% standard laboratory chow, 5% lard, 10% yolk powder, cholesterol 0.2%, 0.5% bile salt), the animals from diabetic group received a single dose of streptozotocin (STZ) solution (40 mg/Kg b.w., 1 mL/Kg b.w., i.p.) whereas control group received citrate buffer 0.1M (pH 4.5). Seventy-two hours later, the DM2 induction was confirmed by measuring fasting blood glucose. The animals were further divided into five groups (n=4/group): Control (normal diet + saline), diabetic control (hypercaloric diet + saline 0.9%) and diabetic (hypercaloric diet + extract at doses of 7.5, 15 or 30 mg of polyphenols/Kg b.w.). Treatment by gavage lasted 21 days. On day 22, all animals were euthanized, and blood were collected. Only the highest dose of the extract (30 mg/Kg) was able to partially reverse fasting blood glucose in diabetic animals. No changes were observed in the levels of fructosamine in any of the groups, when compared to the control (p>0.05). In the lipid profile, there was a reduction in triglyceride levels in animals treated with doses of 15 and 30 mg/Kg of Cherry of the Rio Grande extract, compared to the untreated diabetic group. HDL cholesterol levels were equivalent in all experimental groups. These data indicate that the extract from E. involucrata fruits may have potential benefits in reducing glucose and lipid parameters altered by diabetes.

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