It is well known that reactive species of oxygen (ROS) and nitrogen (RNS) are naturally produced by the human metabolism and exert beneficial functions when they are present in low concentrations. However, in high concentrations, they can be very harmful. Jabuticaba seeds contain high contents of phenolic compounds, which can demonstrably behave as powerful antioxidants. Thus, jabuticaba seed extracts could act in the deactivation of those reactive species. Considering this, the aim of this work was to evaluate the deactivation capacity of the seed extracts of five varieties of jabuticaba towards the ROS and RNS. The varieties were Myrciaria jaboticaba (Vell.) O. Berg (Sabará), Myrciaria cauliflora (DC.) O. Berg (Paulista), Myrciaria coronata Mattos (Coroada), Myrciaria cauliflora (DC.) O. Berg (Hibrida) and Plinia ssp. (Pintada). ROS and RNS were evaluated using the methods of hypochlorous acid-scavenging, peroxynitrite-scavenging, superoxide radical-scavenging, hydrogen peroxide-scavenging and oxygen radical absorbance capacity. The more promising results for the deactivation of reactive species by the extracts of jabuticaba seeds were: hypochlorous acid deactivation by Pintada variety (IC50 31.29 µg.mL-1); superoxide radical deactivation by Paulista variety (IC50 16.15 µg.mL-1); anion peroxynitrite deactivation, without sodium bicarbonate, by Hibrida variety (IC50 24.87 µg.mL-1); anion peroxynitrite deactivation, with sodium bicarbonate, by Coroada variety (IC50 27.89 µg.mL-1); radical peroxyl deactivation by Paulista variety (694.43 μmol TE g-1) and hydrogen peroxide deactivation by Sabará variety (49.11% inhibition in the concentration of 125 µg extract.mL-1). It was possible to determine the significant capacity of ROS and RNS deactivation by the seed extracts of all jabuticaba varieties, proving their antioxidant potential. This work also demonstrated the importance of these samples and the possibility of using them to develop new products in the pharmaceutical, cosmetic and food industries.