THE EFFECT OF VITAMIN D THERAPY ON DYSLIPIDEMIC PATIENTS WITH OR WITHOUT SUB-CLINICAL HYPOTHYROIDISM: A RANDOMISED CONTROLLED STUDY

Introduction and Objective: Low Vitamin D status is associated with worsened cardiovascular outcome. In this randomized placebo-controlled trial, we aimed to determine the effect of Vitamin D therapy in dyslipidemic and Vitamin D deficient patients with or without sub-clinical hypothyroidism. Method: Patients with or without subclinical hypothyroidism, dyslipidemic and Vitamin D deficient who admitted to the outpatient clinic of the Family Medicine Clinic of Diskapi Yildirim Beyazit Training and Research Hospital between August 2014 and June 2015 were included in the study. A total of 64 patients ( 29 cases with subclinical hypothyroidism , 30 controls) who completed vitamin D therapy for a total of 8 weeks were included in the study. Results and Conclusion: Comparing the two groups, there were no statistically significant differences concerning their age, gender, body mass index (BMI) and lipid profile before the Vitamin D therapy. Following the vitamin D therapy, the TSH levels significantly decreased in the case group (p=0,046). Our study cases had a significantly lower 25 (OH) vitamin D level than those in the control group (p=0.001). While a significant reduction in total cholesterol and trigliserid levels were detected after Vitamin D therapy (p= 0.02 and 0.03), there were no significant differences in the lipid profile of the case group. Vitamin D therapy had reduced TSH levels independently from BMI and lipids. Moreover, Vitamin D therapy caused favorable lipid levels in the control group while there was not significant difference in the case group. According to our study, Vitamin D therapy could be associated with aterosclerosis.