RELATION OF APOLIPOPROTEIN WITH CARDIOVASCULAR DISEASE IN BANGLADESHI POPULATION

Introduction & objective: Coronary heart disease is the commonest cause of morbidity and mortality in developed as well as developing countries like Bangladesh. In this study, apolipoprotein-A1 (apo A-1) and apolipoprotein-B (apo-B) levels were assessed as risk factors for coronary artery disease in Bangladeshi patients. Methods: This was a prospective case-control study in the department of cardiology, university cardiac centre, BSMMU, Dhaka in 2012 where study population was 100 with 50 (40 male and 10 female) cases and 50 (40 male and 10 female) controls. The patients and controls were enrolled follwing the inclusion and exclusion criteria. Results & Conclusions: The mean age of study population was 51.4 ± 10.9 years and mean age of the cases and control was 51.3 ± 10.98 and 51.4 ± 10.9 years respectively. The most effected subjects belonged to age group of 45-54 years. The parameter were evaluated among cases and controls included apolipoprotein- B (apo -B) (113.33 ± 25.96 mg/dl vs 104.27 ± 24.30 mg/dl), apolipoprotein A-I (apo A-I) (95.10 ± 20.50 mg/dl vs 113.47 ± 20.96 mg/dl) and apo-B/A1 ratio was (1.25 ± 0.40 vs 0.95 ± 0.26). There was significant relation of coronary artery disease with low apo A-1 level (p< 0.001) was found, but there was no such relation with apo-B level (p=0.08). Conclusion: The study revealed statistically highly significant relation of coronary artery disease with low apo-A1 level and apo-B/A1 ratio. But large-scale multicentric study is needed to evaluate the exact influence of apolipoproteins with coronary artery disease patients of Bangladesh.