LOW CARBOHYDRATE DIET (LCD) HAVE GREAT EFFECTS FOR WEIGHT REDUCTION AND GLUCOSE/LIPIDS METABOLISM IN MORE THAN 2000 CASES

Introduction and Objective: The standard method of diet therapy for metabolic syndrome has been calorie restriction (CR) for long years. Recently, the low carbohydrate diet (LCD) has become an effective therapy in patients with obesity, diabetes, metabolic syndrome and locomotive syndrome. We have developed the social and medical movement of LCD in Japan for long years, and we will report the efficacy of LCD for 2184 cases and the detail of several cases with glucose/lipid metabolism impairment. Method: The subjects included were 2184 cases with obesity and diabetes, metabolic syndrome, who were on LCD therapy for more than 6 months and evaluated the changes of body weight, HbA1c and lipid profile. Results and Conclusions: We investigated the following study. Study-1; The subjects (n=2184) showed reduction rate of body weight as follows; more than 10% (27%). 5.0-9.9% (32%). 0-4.9% (35%). Study-2; The case is 39 years-old female with elevated HbA1c (10-11 %) for 7 months. After starting of LCD, HbA1c decreased from 10.8% to 6.3%, body weight decreased from 83.2kg to 66.6kg for 6 months. Study-3; The case is 62 years-old men with elevated serum triglyceride (TG) (358-982 mg/dL) for years. LCD decreased serum TG to 207-238mg/dL in 1 year, and 108-144mg/dL in 2 years. From these results, LCD seems to be effective therapy through our clinical experiences, with the pathophysiological speculation of the role of ketone bodies.