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INTRODUCTION This is a case report of a patient with Hepatitis C showing Erythema Nodosum, a rare cutaneous manifestation of the disease. Although uncommon, Erythema Nodosum is associated with systemic diseases like infectious virus diseases, such as Hepatitis C. The more common etiologies for Erythema Nodosum are Streptococcal Infections, Inflammatory Bowel Disease, Sarcoidosis, Tuberculosis or use of certain medications. CASE REPORT A 43-year-old caucasian male presents in the primary care services with an 8-day history of pink painful nodules in the anterior aspect of both lower limbs, suggestive of Erythema Nodosum. The patient also described joint pain, chronic diarrhea, myalgia and extreme fatigue. He has a past history of cannabinoid consumption, denies sexual risk behaviors and belongs to the IV Duvall family stage. After clinical, laboratorial and image investigation, the patient was diagnosed with Hepatitis C and sent to Gastroenterology and Infectiology appointments. CONCLUSION Bearing in mind that Erythema Nodosum can have several probable causes, the aim of the present case report is to remind that this condition can also be a rare cutaneous manifestation in Hepatitis C patients.