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Psychotropic medications excessive use is demonstrated in several countries and also in Brazil. Despite the increase in diagnosis and treatment of mental illness because the major accessibility to health services, unnecessary medication has been associated with damage. This study analyzed the psychotropic prescription dispensed during six months (March to August 2015), in a pharmacy located in a Basic Health Unit Uberaba MG. This period 425 patient were attended and 604 prescriptions dispensed (average of 1.4 medications per patient). The most prescribed drugs were antidepressants (44.86%), among them fluoxetine with 26.32% and amitriptyline with 14.9%. Benzodiazepines were 37.25% of prescriptions (clonazepam 24.83% and diazepam 9.77%). Among anticonvulsant and mood stabilizers carbamazepine appears with 10.26%. Analyzing the prescribing doctors, 68.1% were made by primary health care doctors, 12.9% by psychiatrists, 5.62% by neurologist, 4.8% by endocrinologists. It is noteworthy that there was a reasonable percentage of prescriptions issued undated (18.5%), mainly psychiatrists and neurologists, probably due to difficult access to returns for reassessment. Regarding particularly benzodiazepines, were 225 prescriptions during the period, mostly prescribed by generalists doctors and exchange students (48%), then by GPs (27.5%) and by neurologists and psychiatrists (13%). Although widely prescribed as use continue its necessary that all doctors in general and particularly GPs take care for rational use of benzodiazepines and be able to use other alternatives for insomnia and anxiety treatment.