Improving humanized L-asparaginase production expressed by Pichia pastoris using DoE approach for controlled methanol induction in fed-batches

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Institutions
  • 1 Universidade de São Paulo / Departamento de Engenharia Química
  • 2 Gottfried Wilhelm Leibniz Universität Hannover, Hannover, Germany
  • 3 Universidade de São Paulo / Departamento de Tecnologia Bioquímico-Farmacêutica
Track
  • PHARMACEUTICAL BIOTECHNOLOGY
Keywords
Asparaginase
Bioreactor
design of experiments
Pichia Pastoris
Methanol