This study aimed to evaluate the potential of orange bagasse for the bioethanol production. The bagasse was obtained by the company Gyn Fruit, cut, dried and milled. Moisture was analyzed before and after drying, and dried bagasse with a diameter of less than 300 μm was discarded for interfering in pretreatment. This pretreatment was performed using 2 g dry bagasse, 0.5 g Ca (OH)2, and 50 mL deionized water at 60 °C, 150 rpm for 20 h. The optimize the hydrolysis conditions for bioethanol production using Response-Surface Methodology (RSM), a factorial design of the central composite type was carried out at two levels, with three main factors: HCl concentration, temperature and hydrolysis time. The response functions were the concentration of total reducing sugars) in each case. The results showed that the temperature was the most relevant factor to obtain sugars with the concentration at the best point of 30.15 mg sugars / g biomass. It was not possible to find the optimal region of sugars generation with the studied tracks. It is necessary to increase the temperature range to ensure the total hydrolysis of the biomass.