Solid-state fermentation stands out in the use of solid residues, due to the microbial growth that results in the synthesis of several compounds. Thus, in this study, tests were performed to determine the best amylase production conditions by Aspergillus oryzae. The variables were the fermentation times and the formulation of the culture medium. For the planning of the experiments for the formulation of the culture medium a simplex-lattice mixing planning was used. The best result in amylase production was observed at 72 hours of fermentation, when the medium presented only the cake as a substrate. In all formulations, the formulated medium presented amylolytic activity, a result that adds value to the byproducts of babassu coconut.