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Mixed-Integer Programming (MIPs) contains NP-hard optimization problems with integer and continuous variables, applicable across various industries such as logistics, telecommunications, and finance. Commercial solvers (CPLEX, Gurobi, Xpress) primarily use the branch-and-bound method but are expensive and may become inefficient for large problems. This work proposes the Random-Key Optimizer (RKO), a flexible framework where the user develops a decoding function to handle MIP constraints. The method is applied to the Markowitz portfolio optimization problem with purchase and cardinality constraints as a proof of concept.
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