Nonthermal light-based approaches for improved health care

The field of health care is undergoing a major transformation with the integration of nonthermal light-based technologies, providing innovative, noninvasive approaches for diagnosis, treatment, and prevention. This presentation will cover key modalities, including photodynamic therapy (PDT), photobiomodulation therapy (PBMt), and optical diagnostics such as fluorescence imaging. For therapeutic and preventive purposes, these technologies employ appropriate light wavelengths to elicit targeted biological responses without generating heat, enabling safer and more precise interventions. PDT offers an effective antimicrobial approach for managing infections and contaminated lesions across diverse tissues, while PBMt promotes tissue repair, reduces inflammation, and alleviates pain in a variety of clinical contexts. In diagnostic applications, fluorescence imaging enhances detection capabilities by allowing real-time identification of pathological changes, biofilms, and early-stage lesions. Incorporating nonthermal light-based technologies into routine health care not only improves clinical outcomes but also supports the shift toward personalized and preventive strategies. This presentation will highlight recent clinical findings and emerging applications, emphasizing the transformative potential of nonthermal photonic technologies to redefine therapeutic protocols and promote improved health outcomes for individuals.

This work was supported by Fapesp, CNPq and CNEN.