44ª Reunião Anual Virtual da SBQ

In this work, transfer hydrogenation catalyzed by Ru-MACHO or Ru-MACHO-BH is used for the synthesis of furfurylamines and a-amino acids in two different transformations. For both transformations, green alcohols are used as H-donor and solvent and low catalyst loading (0.5-0.1 mol%) is required. A scope of substrates demonstrates the good tolerance of the method. For the synthesis of furfurylamine is used a reductive amination from furans without the presence of base. The synthesis of amino acids was afforded from the chemoselective transfer hydrogenation of enamides using bot EtOH and iPrOH as H-donor. The one-pot version of this method and the gram scale was also demonstrated. The application of the method and mechanistic studies was also conducted.