Cytotoxicity evaluation and Dereplication Strategy of Phyllanthus spp by UHPLC-HRMS and NMR in Bioassay-Guided Fractionation.

Vol 9, 2023 - 167469
Poster
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Abstract

This study's aim was to conduct bioguided fractionation of Phyllanthus amarus and P.niruri through preparative HPLC, followed by the chemical characterization of fractions via UHPLCQTOF-MSE and NMR techniques. Additionally, the study aimed to establish associations between the identified chemical compounds and their cytotoxicity effects. The results showed that the PhyN 4n fraction from P. niruri exhibits significant potential for further exploration in the quest for novel anticancer agents.

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Institutions
  • 1 Universidade Estadual de Londrina
  • 2 Universidade Federal do Pará
  • 3 Empresa Brasileira de Pesquisa Agropecuária
  • 4 Universidade Federal do Ceará - UFC
  • 5 Embrapa Agroindústria Tropical
Track
  • 1. Biodiversity and Natural Products
Keywords
Dereplication.; Metabolomic.; “quebra-pedra”.; Cytotoxicity.; Cancer