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Question
Differential Sensitivity of HCC-1937 and MDA-MB-231 Cells
Publication: Characterization of the Response to Treatment with 5-Fluorouracil Combined with the APE1 Inhibitor, APX2009, in Triple-Negative Breast Cancer Cells
Very good work and presentation, Isabel, congratulations!. My question is about which molecular mechanisms could explain the greater sensitivity of the HCC-1937 cell line compared to MDA-MB-231 when treated with the combination of 5-Fu and APX2009? -
Other
PBM and Proliferation Gene Regulation in MCF-7 Cells
Publication: Evaluation of the Effects of Photobiomodulation with Low-Power Red Laser and Ultraviolet A LED on Cell Survival and Antioxidant Markers in MCF-7 Breast Cancer Cells
Great presentation Ana Clara! Considering that PBM with red laser and UVA-LED did not modulate survival or antioxidant genes but increased MKI67 expression, how do you interpret the specificity of PBM in regulating proliferation-related genes in MCF-7 cells? -
Question
A2 β-casein
Publication: Gene Regulation of β-Casein and Its Application to Health
Hello Gabrielle, good morning. Congratulations on the presentation. How can genetic selection for the A2 β-casein variant influence consumer health while also affecting the productive efficiency of dairy herds? -
Question
PBM in patients
Publication: Red and infrared laser exposure upregulates NF-kappaB/p65 in triple-negative HCC1937 breast cancer cells.
Very good your presentation Rebecca! Since infrared laser exposure activates NF-κB and upregulates IL-6 and IL-8 in BRCA1-mutant HCC-1937 cells, could these photobiomodulation parameters potentially interfere with cancer therapy or promote tumor progression these patients?
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