Therapeutic plasma exchange for neuromyelitis optica attacks: Evidence and challenges from a real-world cohort from Brazil

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Abstract

Therapeutic plasma exchange (TPE) can improve disability recovery after neuromyelitis optica spectrum disease (NMOSD) attacks, but its effectiveness and safety in Latin-American patients with access barriers and diverse ethnicity is underexplored. We carried out a retrospective cohort study with NMOSD patients that underwent TPE. 84 NMOSD attacks in 68 patients were evaluated. Despite a median 25-day delay from symptom onset to TPE, 65,5% of patients showed significant improvement. Adverse events occurred in 39% of patients, usually transitory and with no fatalities.

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Institutions
  • 1 University of São Paulo Faculty of Medicine Clinics Hospital
  • 2 Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
  • 3 Pontifical Catholic University of Rio Grande do Sul
  • 4 Neurology Department - Hospital das Clínicas São Paulo University, Sao Paulo, Brazil
Track
  • 6. NMO, ADEM and CIS
Keywords
Neuromyelitis optica spectrum disorder
plasmapheresis
Relapse (attack, flare-up)
time to treat
NMOSD