DIGITAL PLATFORM FOR NMR ANALYSIS INTEGRATED WITH GLP PRINCIPLES

The implementation of Good Laboratory Practices (GLP) in analytical laboratories requires strict
control of procedures, data traceability, and standardized documentation¹. As an additional mea-
sure, a digital platform was developed and implemented at the Nuclear Magnetic Resonance (NMR)
Laboratory of the Federal University of São Carlos (UFSCar). This system enables complete track-
ing of NMR workflows in accordance with GLP guidelines², improving documentation, accessi-
bility, and data integrity. Development followed a structured methodology, including observation
of routine procedures and collaboration with analysts to identify documentation gaps and align
system features with GLP requirements. The interface was designed to be intuitive, facilitating
use across varying levels of technical expertise while maintaining adherence to standardized pro-
cedures. The platform allows full registration of analytical workflows, including sample identifi-
cation, client data, mass, solvent, instrument configuration, and acquisition parameters for 1D and
2D NMR experiments, and also records the final destination of samples. For quantitative applica-
tions, automated calculations based on qNMR principles estimate analyte purity or potency. These
are embedded in the final report using inputs such as sample mass, molecular weight, number of
nuclei, and internal standard reference, reducing manual handling and ensuring compliance. Built
with modern web technologies (Firebase, React, Google Apps Script), the system supports real-
time data input on both desktop and mobile devices. Each analyst has access to a personalized
report interface. Access control ensures data segmentation, and finalized reports are immutable,
exportable, and traceable. Sample reuse is prevented by automatic locking once a report is issued.
Since implementation, the platform has reduced transcription errors, improved documentation con-
sistency, and standardized reporting. It is now a central component of the laboratory’s quality
management practices, supporting full compliance with GLP standards. Future development will
integrate currently decentralized information - such as data on analysts, clients, solvents, instru-
ments, and experimental protocols - into a unified digital environment, consolidating the system as
a comprehensive Laboratory Information Management System aligned with GLP.