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INTRODUCTION AND OBJECTIVE: UNAIDS estimates that in 2011, 34.2 million people were living with HIV. In Latin America, the number of cases were estimated in 1.4 million in 2010, of whom one-third were from Brazil. The aim of the study was to analyze the characteristics and trends of the cases of HIV infection in Brazil. METHOD: A retrospective cross-sectional study was performed using data collected at Notifiable Diseases Information System Database (SINAN), Mortality information systems (SIM) and Laboratory Tests Control System (SISCL) through the notification of patients with HIV infection from 2000 to 2013. RESULTS AND CONCLUSIONS: A total of 529.824 cases were recorded between 2000 and 2013. From 2000 to 2013 there was a 24% increase in incidence of HIV infections in Brazil, being 2011 the highest infection rate (40.805). Comparing between sexes, men had a higher number of cases (326.498 against 203.293). Specific group risks heterossexuals, homossexuals, bisexuals, injectable drug users (IDU) answered for 68%, 15%, 6% and 7,5% of infections respectively. Analyzing the data, we verified an increase in incidence, which could be explained by a failure in preventive strategies. Males were at a higher risk of infection, which could be explained by a higher probability of transmission between MSM partners. The age group 30-39 years was associated with higher incidence, but amongst the ages was verified that elderly groups (60-69, 70-79 and >79 years) had greater increase in incidence, that could be explained by a longer sexual life.