The differential diagnosis between cutaneous sarcoidosis and tuberculoid leprosy ( MHT ) is not easily achieved because the clinical and histological findings may be similar. The texture analysis of reticulin fibers and the morphometric analysis of the skin lesions could help to distinguish the two processes and add elements to the understanding of the pathogenesis of both diseases. Skin samples from patients with MHT and sarcoidosis have been studied. Clinical data of each patient were obtained from HC - UNICAMP medical files. Histomorphometric analysis of the specimens were recorded. Digital images from reticulin network were acquired in a blinded way and analyzed through ImageJ software.