The topical application of nitric oxide-releasing biomaterials has shown to be effective for promoting the increase of dermal vasodilation and wound healing. The main aims of this work are the development of a new platform for topical NO release, based on polyethylene terephthalate (PET) meshes impregnated with a NO-releasing polynitrosated polyester (PNPE) and the correlation of the kinetics of NO release in vitro with the dermal vasodilation in vivo.