Cholinergic antiinflammatory pathway participate of control of inflammatory response through a7 subunit nicotinic acetylcoline receptor (a7AChR), JAK2 and STAT3 proteins. Reduced activity of this pathway lead to high level of inflammatory cytokines. The objective was evaluate the effect of maternal consumption of high-fat diet fed during pregnancy and lactation in liver. We observed that offspring from HFD dams seems to have cholinergic antiinflammatory pathway impaired.