In DNA sequences, regions where 3-5 nucleotide repeats themselves is often found in the non-coding areas. These sequences are called microsatellites. Recent studies attribute the presence of MS to diverse diseases. Using Molecular Dynamics simulations, we studied how specific MS affect the DNA mechanical properties. Our results show that the presence of MS tend to make the DNA ‘softer’ to mechanical elongation. Further studies are needed to clarify the biological implications of this behavior.