Currently antitumor therapies consist in the neoplasic cells attack by chemotherapy and radiotherapy. Compounds that are capable of acting as agonists of Toll-like receptors (TLRs) may represent promising candidates to be developed as medicaments against cancer. Thus, the general objectives of this study are to characterize and compare the histologic effects of P-MAPA associated with the chemotherapeutic agent Gemcitabine to treat pancreatic cancer in rats.