Amphiphilic polyurethanes, were loaded with sodium diclofenac, a anti-inflammatory drug, using ethanol solutions. The drug release in PBS buffer solution was investigated. The sodium diclofenac sorption in the hydrogels increased with the drug concentration in the loading solutions and decreased with increasing crosslinking density of the hydrogels. The drug release in PBS solutions achieved a linear dependence with time after 50 min of liberation, consisting of a controlled drug release.