The Bipolar Disorder is a psychiatric illness that affects 1% of the global population. Having in mind that diagnostics of the BD is difficult and based on clinical evaluation, our current research has for aim the comparison of the metabolic profiles among control group and the patients with BD. To enlarge results obtained in previous studies on BD biomarkers, the blood serum samples were analyzed using ¹H Nuclear Resonance Magnetic spectroscopy and chemometrics methods in the data analysis.