The main of the present study was to compare the acute molecular response after Low-intensity Endurance Exercise with Blood Flow Restriction (LI-EE+BFR), High-Intensity Endurance Exercise (HI-EE) and High-Intensity Resistance Exercise (HI-RE). There were significant increases of PGC-1-α and VEGF mRNA expression to HI-EE. There were no changes in protein phosphorylation. The results indicate that acute HI-EE increases more muscle PGC1-α mRNA expression than LI-EE+BFR.