We have shown that offspring from obese dams present elevated hepatic triacylglycerol synthesis, diminished fat acid oxidation, lower miR-370 and higher miR-122 expression. Here we overexpressed miR-122 in hepatic cells in the presence or absence of palmitate. Overexpression of miR-122 reverted deleterious effects observed when cells are treated with palmitate. Our data suggests that miR-122 expression may be related with the epigenetic modifications in lipid metabolism of obese dams offspring.