Also published on: XV SO 2021, XVII SO 2023, XVIII SO 2024
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Publication: CYTOTOXIC POTENTIAL OF SYNTHETIC SUBSTANCES NAPHTHOQUINONES WITH ACRIDINE IN ORAL SQUAMOUS CELL CARCINOMA
Como aluno de iniciação científica, quais foram suas atividades no projeto e nestes resultados?
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Publication: CYTOTOXIC POTENTIAL OF SYNTHETIC SUBSTANCES NAPHTHOQUINONES WITH ACRIDINE IN ORAL SQUAMOUS CELL CARCINOMA
Parabéns pelo trabalho! O delineamento e a apresenação dos dados está clara e objetiva. Entendo que é um screening inicial para avaliar a citotoxicidade da droga, porém como o MTT avalia a atividade/viabilidade mitocondrial, seria interessante vocês terem realizado outros testes, como viabilidade celular com azul de tripan ou células viáveis com coloração por cristal violeta. Esses testes chegaram a ser realizados?
Outra pergunta é: vocês pretendem testar essa droga in vivo, enxertando essas células de CCE em camundongos imunossuprimidos, ou em outros modelos experimentais de câncer, como por exemplo, melanoma murino com células B16F10 e câncer de mama murino com células 4T-1?
Obrigada
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NEW SUBSTANCES BASED ON NAPHTHOQUINONE BEARING ACRIDINE NUCLEUS WITH BIOLOGICAL ACTIVITY IN ORAL SQUAMOUS CELL CARCINOMA
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