BATCH PENICILLIN PRODUCTION UNDER TEMPERATURE PROGRAMMED

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Abstract

In this study, the usefulness of the Pontryagin’s maximum principle was illustrated for the optimization and operation of a penicillin production bioprocess conducted in batch mode, under isothermal and non-isothermal conditions. By applying this principle, it was possible to determine the optimal profile of temperature that maximizes the antibiotic concentration at the end of the bioprocess and the solution found was considered feasible for implementation in real cases.

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Institutions
  • 1 Faculdade de Ciências Farmacêuticas / Universidade Estadual Paulista “Júlio de Mesquita Filho”
  • 2 Departamento de Matemática / Facultad de Ciencias Exactas / Universidad Nacional de Salta (UNSa)
Track
  • 4. Modeling, Instrumentation, and Control of Bioprocesses
Keywords
Batch bioprocess
penicillin
Optimization
Pontryagin’s maximum principle
Modeling and simulation