Over the last few years, there have been an increasing number of countries around the world with biofuels mandates. At the same time, the biochemical conversion process for production of biofuel from lignocellulosic biomass has finally been reaching commercial scale. While the high-volume biofuel helps to meet bioenergy targets and mandates, the so-called Biorefinery has yet to be fully realized. This presentation will highlight some general trends in biorefining lignocellulosic biomass into a biofuel-driven facility and discuss on perspective and opportunities to tailor the biorefining process steps to utilize, with minimum processing steps, carbohydrate streams into low-volume products such as nanomaterials and food additives, in an attempt to improve the recovery and utilization/valorization of biomass feedstock fractions within a biorefinery system producing bioethanol. Examples of processing sugarcane-bagasse into high-volume low-value bioethanol and low-volume high-value food additives and nanomaterials from sugarcane bagasse will be presented and discussed as a potential opportunity for integration into a biofuel-driven Biorefinery