80845

Antifungal Susceptibility Profile of Candida isolates from Patients at the University Hospital of Londrina

Roseane Galdioli Nava 1 ; João Gabriel Material Soncini 1 ; Leticia Caraski 2 ; Izadora Roza Miranda 2 ; Evelyn Poliana Candido 2 ; Eduardo Cavalcante Rabelo Mendes 2 ; Giovanna Tavares Callado 2 ; Gerusa Luciana Gomes Magalhães 2 ; Marsileni Pelisson 2 ; Eliana Carolina Vespero 2
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The objective of this study was to determine the in vitro susceptibility profiles to five antifungal agents (caspofungin, fluconazole, fluocytocin, micafungin, voriconazole) in the University Hospital of Londrina State University of Candida spp. in the years 2014 until 2016. Cultures of various clinical materials were identified in the Vitek®2 bioMérieux system, following the breakpoints recommended by CLSI M27-S4 and EUCAST version 6.1. Among 1359 Candida isolates evaluated, non-C. albicans species (831; 61.15%) were more frequent than C. albicans (528; 39%). The non-C. albicans species included C. tropicalis (330; 24 %), C. glabrata (272; 20 %), C. parapsilosis (142; 11 %) and other species 87 (6%). Based on the results, it is concluded that the use of diagnostic methodologies that determine the species and the sensitivity profile of Candida samples involved in infectious processes become increasingly important for the application of appropriate treatment and to avoid the indiscriminate use of antifungals.