Quinoline derivatives are among the aza-heterocyclic compounds that arouse the interest of the scientific community for their biocompatible properties, being used in several medicinal applications. The objective of this work is promote the synthesis of hydroxyquinoline derivatives and studies the phosphorylation of hydroxyl groups present in quinoline derivatives, to verify their potential application as fluorogenic probes. The insertion of phosphate groups aims to facilitate the transport of quinoline derivatives in the organism, as well as the participation in protein regulation mechanisms.
In this work we describe the synthesis of different hydroxyquinoline derivatives using NbCl5 as promoter by multicomponent reaction, with good yields and reaction times. All hydroxyquinolines synthesized were submitted a solvatochromism study in different solvents, with good results for potential applications as fluorescence probe. In figure 1 is showed the results from hydroxyquinoline obtained from p-hydroxybenzaldehyde, p-nitroaniline and phenylacetilene.