The industrialization process has increased because of the population increase, and tons of solid, liquid, and gaseous waste is produced and can cause severe environmental and human health problems if released to the environment without proper treatment1. Therefore, the search for simple methods to identify them and, if possible, extract them from the environment has become an attractive field in recent years. In this scenario, it was synthesized chemosensors to identify such hazardous species. The synthesis of 2-Bromo-N-(thiazole-2-il) acetamide (1) was made with the goal of anions interacting due to the pairs of free electrons of nitrogen and sulfur and H of group NH. The characteristic was performed employing 1H-NMR, showing the following signals: (δCDCl3 300 MHz) 4.08 ppm (s, 2H, CH2),7.08 (d, 1H, S-CH),7.55 ppm (d, 1H, N-CH) and 10.97 (sl, NH). The UV-Vis spectrum of this ligand has bands at 217 nm and 274 nm, characteristic of typical  →  * transitions. The ligand (1) was functionalized in the calixarene matrix, originating the ligand (2). The characterization of this new species was made employing 1H-NMR, showing the following signs: (δCDCl3) 1.18 and 1.25 ppm (2s, 36H, tBu), 3.54 ppm (d, 4H, Spin AB), 4.26 ppm (d, 4H, Spin AB) 4.83 ppm (s, 4H, CH2),7.06 ppm (1s, 8H, m-ArH), 7.10 ppm (d, 2H, S-CH),7.38 ppm (d, 2H, N-CH),8.83 ppm (s, 2H, OH) 12.36 ppm (sl, 2H, NH). The spectrum of UV-Vis of this composition presents bands in 272 nm, 283 nm, and 290 nm characteristics of bands of type →*. Ligand (1) presented a good interaction with the anions F-, Ac- and PO43- via UV-vis by decreasing 272 nm band and the emergence of 318 nm band. The hydrogen bond of the NH group with the F- anion without intermediates were observed in the spectrum of 1H-NMR. Similarly, ligand (2) with ions F- interacting was observed in approximately 303 nm. The same effect is also observed in the spectra of interaction with Acetate and dihydrogen phosphate. The ligands (1) and (2) interactions with the anion’s fluoride, phosphate, and acetate are potential ionic chemosensors.