Thiazoles are heterocycles compounds with five membered ring that contain three carbon atoms, one sulphure atom and one nitrogen atom. Recently, the synthesis of bis-imines by multicomponent reaction was reported using thiocarbohydrazide, a ketone and an aromatic aldehyde. Multicomponent reactions combine elements of an ideal synthesis such as operational simplicity and atom economy, in addition to that there is also the reduced number of steps. This molecules were synthesized from thiocarbohydrazide (0.5 mmol), an aromatic aldehyde (2 mmol) and 2-bromoacetophenone (0.5 mmol), using p-sulphonic acid calix[4]arene as the catalyst. The interest in bis-imines thiazoles is due to some biological activities already reported in the literature such as antituberculosis, antibacterial, antimalarial, antifungal, inhibitors of human monoamine oxidase A and B enzymes and antitumor. Six bis-imines thiazoles have been synthesized in yields ranging from 12% to 70%.