This work describes the total synthesis of (+)-Raputindole A which features an iridium-catalyzed cyclization, an enzymatic resolution which allows the preparation of enantiomerically pure benzylic alcohol, a methallylation to install the butenyl side chain  and a Heck reaction to coupling the northern and southern parts. In our proposal (+)-Raputindole A was prepared in 10 steps (LLS) and 3.3% overall yield.