Novel 3-nitro-1,2,4-triazole derivatives with potent activity against Trypanosoma cruzi in an intracellular model

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  • Presentation type: Sessão Coordenada PG - Pós Graduando
  • Track: Química Medicinal - MED
  • Keywords: Synthesis; Chagas; Trypanosoma cruzi; Nitrotriazole;

Authors:

  • 1 Fundação Oswaldo Cruz/ Farmanguinhos/ Departamento de Síntese de Fármacos, LASFAR / Instituto de Ciências Biomédicas, UFRJ
  • 2 Fundação Oswaldo Cruz

Novel 3-nitro-1,2,4-triazole derivatives with potent activity against Trypanosoma cruzi in an intracellular model

Cheyene Almeida Celestino Menozzi

Fundação Oswaldo Cruz/ Farmanguinhos/ Departamento de Síntese de Fármacos, LASFAR / Instituto de Ciências Biomédicas, UFRJ

Abstract

Five derivatives were synthesized in overall good yields (9-45%). These proved to have a good absorption profile in silico and showed high potency against Trypanosoma cruzi, higher than benznidazole.

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