New pyrazolopyrimidine and triazolopyrimidine derivatives with potential activity anti-P. falciparum

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  • Presentation type: Exposição de Pôster
  • Track: Química Medicinal - MED
  • Keywords: malária; Pyrazolopyrimidine; Triazolopyrimidine; quinoline;

Authors:

  • 1 Fiocruz
  • 2 Síntese de Fármacos / Farmanguinhos / Fundação Oswaldo Cruz
  • 3 Universidade de São Paulo
  • 4 Instituto de Física de São Carlos - USP
  • 5 Fundação Oswaldo Cruz

New pyrazolopyrimidine and triazolopyrimidine derivatives with potential activity anti-P. falciparum

Gustavo Peixoto Machado

Síntese de Fármacos / Farmanguinhos / Fundação Oswaldo Cruz

Abstract

Eight pyrazolopyrimidine and triazolopyrimidine derivatives were synthesized in 12-30% overall yield and in vitro evaluated against P. falciparum. Compound 13 was the most potent derivative.

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