Molecular docking and fluorescence based enzymatic inhibition assay: a study of T. cruzix0092s CYP51 inhibition by heterocyclic compounds

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Details
  • Presentation type: Sessão Coordenada PQ - Pesquisador
  • Track: Química Medicinal - MED
  • Keywords: Trypanosoma cruzi; Chagas disease; CYP51; molecular docking; fluorescence enzymatic assay;

Authors:

  • 1 Universidade Federal Rural do Rio de Janeiro
  • 2 York University - Toronto/CA

Molecular docking and fluorescence based enzymatic inhibition assay: a study of T. cruzi_x0092_s CYP51 inhibition by heterocyclic compounds

Carlos Sant Anna

Universidade Federal Rural do Rio de Janeiro

Abstract

The T. cruzi CYP51 inhibition activity of heterocyclic compounds was evaluated by docking and a fluorescence-based enzyme inhibition assay, with promising results for triazole piperine derivatives.

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