Synthesis of New Schiff Bases (N-Aryl)Phosphoramidic. Possible Microbiocidal

Schiff bases are products of the reaction of primary amines with aldehydes or ketones and represented by the azomethine group (-CR = N-). Bases are considered pharmacophores of multiple actions1. Krátký, reported the strong inhibition of strains of Staphylococcus aureus by the action of the Schiff base (1)1. Another class of compounds of relevance is the class of phosphoramidates that stand out in medicinal chemistry. The Phosphoramidates are found in prodrugs by potentiating the original drug. For example, Kolodziej et al., Obtained a series of prodrugs (AZT-arylphosphoramidates), and all derivatives showed superior viral inhibition to standard AZT, with emphasis on (2) and (3) 2. In this way, this work proposed two reactional steps to obtain a series of Schiff Bases (N-aryl) phosphoramidic. The first is to obtain intermediate (6)3. The second is the reaction of 6 with selected aldehydes4. (Scheme-1). However, 6 has already been obtained and characterized. The reaction aiming at synthesis 8 is already in progress, but adjustment is being implemented to obtain 8a. After obtaining 8, the biological tests will start with research groups of interest.