SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COMPLEX NITROSYLS

Cardiovascular diseases are one of the leading causes of death worldwide, often caused by endothelial dysfunction. In medical emergencies, sodium nitroprusside (SNP), Na2[Fe(CN)5NO], is widely used. However, this drug causes undesirable effects, such as strong hypotension and release of cyanide in the body. In view of this, novel compounds which may act as NO-releasers in vivo are desirable. In this work, coordination compounds containing 5-azaindole and nitrosyl group were synthesized and characterized by spectroscopic and electrochemical techniques and vasodilation experiments were performed on aortic rings of wistar rats. The complexes cis-Ru(NO)(phen)2(5-aza)](PF6)3 (FOR095) and cis-[Ru(NO)(bpy)2(5- aza)](PF6) presented NO stretching frequency around 1943 cm-1, characteristic of the nitrosyl (NO+) group. In the UV-VIS region, internal ligand electron transfer bands and MLCT bands were observed for this type of compounds. By the nuclear magnetic resonance technique, the compound FOR095, it was obesrved signals related to the presence of 22 H atmos, confirming part of the proposed structure. In the cyclic voltammogram, potential waves were observed for the redox process centered on the nitrosyl group - {RUN0}617. The chemical reduction by azide corroborates this assignment. The FOR095 complex had vasodilator action on wistar rat rings, with similar efficacy to the SNP, and obtaining a total block in the presence of ODQ, indicating a mechanism dependent on nitric oxide.