Synthesis and characterization of new Zn(II) complexes designed as prototypes for chemotherapeutic treatment of bacterial infections

Nowadays is a worldwide necessity the demand for new bactericidal compounds, capable of effectively combating and even being active against multiresistant bacteria¹. In this sense, the use of inorganic compounds has been described by several research groups, where the incorporation of a metal ion can result in improved biological activities, low resistance and tolerable side effects, when compared to the free organic ligands². This work describes the synthesis and characterization of two coumarin derivatives (IM1 and IM2) and their respective ZnII complexes (IM1-Zn and IM2-Zn). The ligands and the metal complexes have been prepared according to the Scheme 1. All compounds have been characterized by ¹H NMR and Infrared spectroscopy. The ¹H NMR spectra of IM1 and IM1-Zn are shown in Fig 1. The spectrum of the IM1-Zn showed that the signals of the hydrogens nearby the coordination points were shifted to lower field suggesting coordination through the iminic nitrogen and the carbonyl oxygen. The characterization of the compounds by other techniques such as X-ray diffraction and elemental analysis are underway.