The Value of Iron Imaging and Central Vein Sign in the Diagnostic and Follow-up of Multiple Sclerosis

- Introduction and timeline: The updates of the diagnostic criteria and the correct therapeutic management have provided a better quality of life and prognosis for the patients.

- Objectives: (1) to review and illustrate the imaging patterns of typical and atypical multiple sclerosis lesions and (2) to describe the importance of imaging findings based on pathophysiology in the accurate diagnosis and monitoring of multiple sclerosis.

 - Methods (based on cases): Mc Donald 2017 diagnostic imaging criteria for multiple sclerosis were applied. Then, the analysis of image findings based on pathophysiology was added.     

- Discussion: The analysis of diagnostic imaging criteria and imaging findings based on pathophysiology have been increased (1) the diagnostic accuracy; (2) early diagnosis; (3) monitoring of disease activity and therapeutic response and (4) evaluates disease progression and establishes prognosis.

- Conclusion: The integration of imaging findings based on pathophysiology in the diagnostic criteria of Mc Donald 2017 for imaging reduce errors of diagnostic interpretation and increase monitoring of disease activity and therapeutic response, especially of atypical lesions.