Antiprotozoal potential of the alkaloids isolated from the Amazon plant Malouetia tamaquarina (Apocynaceae) and its endophytes against Neglected Tropical Diseases (NTDs).

Vol 9, 2023 - 167319
Poster
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Abstract

Extracts of Malouetia tamaquarina and its endophytes presented antiprotozoal potential. Novel alkaloids (1 and 2) isolated from the bark of M. tamaquarina showed significant activities against Trypanosoma brucei rhodesiense (IC 50 of 20.4 and 2.3 ug/mL) and Plasmodium falciparum (IC 50 of 7.5 and 0.62 ug/mL) respectively. Also, from the endophytic fungus Cosmospora sp. (MT30), two fatty acids and colletorin B were isolated, and the evaluation of their biological activities is still in progress.

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Institutions
  • 1 Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP), Universidade de São Paulo (USP)
  • 2 Instituto Nacional de Pesquisas da Amazônia
  • 3 Universidade Estadual Paulista “Júlio de Mesquita Filho”
  • 4 Universidade de São Paulo
  • 5 Empresa Brasileira de Pesquisa Agropecuária
  • 6 University of Münster
Track
  • 1. Biodiversity and Natural Products
Keywords
trypanosomiasis; malária; Natural products; Apocynaceae