SPEEDING-UP MOLECULAR ANALYSIS USING MULTIPLE FID ACQUISITION EXPERIMENTS

Speeding-up NMR molecular analysis is an important research field which has been continuously advancing since NMR early days. The relevant benefits are clear and evident:

• Reduce the time per analysis directly reduce its cost
• Gaining spectrometer time to analyze new samples

Many interesting tools and concepts have been appearing in last decades. Concretely, our experience focuses on the development of new NMR experiments using TS (Time-Shared), SA (Spectral Aliasing) and MFA (Multiple Fid Acquisition).

MFA strategy is an interesting strategy that allows the acquisition of different structural information in a single experiment. Basically, MFA experiments consist in the design of pulse sequence experiments which accommodate several acquisition windows per experiment, each registering different relevant information for the structural molecular characterization. The methodology brings a corresponding important time benefit. Last year, we have reported several new NMR experiments designed with MFA strategy and herein we would present the most relevant achievements. The overall discussion will be mainly focused on the sensitivity gains per time unit of the presented experiments.