¹ Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil and 2Vice-presidency of Research and Reference Laboratories, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil ;

² Tropical Medicine Research Center of Rondonia (CEPEM), Rondonia; Brazil and Federal University of Rondonia (UNIR), Rondonia, Brazil. ;

³ Instituto Leonidas e Maria Deane, Fiocruz, Manaus, Brazil ;

⁴ National Institute of Infectious Disease, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil ;

⁵ Laboratory of Pharmacokinetics (Sefar), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil ;

⁶ Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil ;

⁷ Tropical Medicine Research Center of Rondonia (CEPEM), Rondonia; Brazil ;

⁸ National Programme of Malaria Control, Ministry of Health, Brasília, Brazil. Corresponding ;

⁹ Liverpool School of Tropical Medicine, Liverpool, UK